Re: [問題]練重訓減緩雄性秃?
※ 引述《kuwawa (庫瓦瓦)》之銘言：
: ※ 引述《ashin1069 (謝金燕我可以)》之銘言：
: : 我是說真的，這也是藥師跟我說的
: : (以下是很多人應該知道的)
: : 練肌肉需要 (分泌) 睪固酮與肝醣
: : 所以練肌肉到一個程度的時候
: : 會有可能導致睪固酮分泌不足
: : 所以在運動之前可以去藥局買銀杏 (或是銀杏膜衣錠)
: : 運動之前吃，可以促進多增加分泌睪固酮
: : 且可以讓血液末梢流動順暢
: : 大家可以參考看看 (或是可以再詢問藥師細節)
: 借這篇文章內容問一下,
: 依照ashin1069大大所說的, 練肌肉會消耗睪固酮,
: 那是否可減緩雄性秃
: 我是漸進性雄性秃, 已經努力掙扎近十年.
: 之前有吃波斯卡來壓抑睪固酮, 但近半年來為了練muscle而停藥
找到一篇網路文章, 節錄相關重點.
大意就是, 肌肉需要的是原始的睪固酮(Testosterone), 而Proscar或柔沛等藥物是
抑制 將睪固酮 轉化成二氫睪固酮( DHT)的 酵素, 並非抑制睪固酮的分泌, 所以對
肌肉不會有直接的影響 .然而(我恨然而), DHT對神經系統,以及肝有影響, 所以
服用Proscar的某些人仍然會覺得運動表現下降不少.
(ps, 我不太確定 "and greater recoverability" 的含義, 難道是指肌肉的recovera-
bility? 但這樣解釋不就又對肌肉有直接影響了?)
Testosterone Is The Active Androgen In Muscle
Skeletal muscle is unique from other androgen dependent tissues in the body.
It actually contains little or no 5-AR, so little or no DHT is actually
formed in the muscle. In addition to this, any DHT that is formed, or that is
already present in the blood and travels to the muscle, is quickly
deactivated by an enzyme called 3alpha-hydroxysteroid reductase (3a-HSD).
So at least as far as muscle is concerned, testosterone is the primary active
androgen. This is not to say that administering exogenous DHT is not without
any anabolic effect. It actually does have some anabolic activity in the
muscle, albeit significantly weaker than that of an equal amount of
testosterone. This is due to its quick breakdown by 3a-HSD into the weak
metabolite 5alpha-androstan-3a, 17b-diol. If this enzyme were somehow
blocked, it is likely that DHT would exhibit very potent anabolic effects on
muscle.
It is important to understand that even though testosterone is the active
androgen in muscle, and DHT exhibits relatively little direct anabolic
effects on muscle in men, DHT is still very important for the full
performance enhancement effects from testosterone. What I specifically mean
here are the effects of DHT on the central nervous system that lead to
increased neurological efficiency (strength), and increased resistance to
psychological and physical stress—not to mention optimal sexual function and
libido.
I have heard several anecdotal reports of individuals who have stacked
testosterone with Proscar (a 5-AR inhibitor) and have noticed significantly
reduced performance enhancement effects. What's going on here? We know it
couldn't be due to the inhibition of the direct anabolic activity of
testosterone on muscle anabolism. Most likely it is due to the reduction of
androgenic effects in other parts of the body that contribute to the
ergogenic effects. Specifically the CNS, which is stimulated by androgens to
increase neural output leading to greater strength and greater
recoverability. Another possibility is a reduction in the production of
androgen dependent liver growth factors (such as IGF-1), since DHT is an
important androgen in the liver.
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◆ From: 24.6.100.140
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